Zyvox Drug Interactions

If you are taking Zyvox, be aware that this antibiotic can cause serious reactions with many other medications, such as Prozac, albuterol, methadone, and dopamine. Reactions are even possible after treatment ends, as the drug's effects continue for two weeks after stopping it. To reduce your risk of potentially life-threatening interactions with Zyvox, tell your healthcare provider about all of your current medications.

An Overview of Interactions With Zyvox

Zyvox^® (linezolid) can potentially react with a number of other medications. Because there are so many Zyvox drug interactions that may be dangerous, it is important to check with your healthcare provider before taking any medications, whether prescription or over-the-counter (OTC), while you are taking Zyvox.

The effects of this medication may continue for two weeks after you stop taking it. Therefore, you may be at risk for drug interactions if you recently took Zyvox.

Some of the medicines that may lead to serious Zyvox drug interactions include but are not limited to:

Altretamine (Hexalen^®)
Antidepressants, such as:
- Miscellaneous antidepressants, such as:

- - Bupropion (Aplenzin™, Budeprion XL^®, Budeprion™ SR, Buproban^®, Wellbutrin SR^®, Wellbutrin XL^®, Wellbutrin^®, Zyban^®)
  - Mirtazapine (Remeron^®)
  - Nefazodone (Serzone^®)
  - Trazodone (Desyrel^®) or trazodone ER (Oleptro™)
  - Vilazodone (Viibryd™)

- Monoamine oxidase inhibitors (MAOIs), such as:

- - Isocarboxazid (Marplan^®)
  - Phenelzine (Nardil^®)
  - Rasagiline (Azilect^®)
  - Selegiline (Eldepryl^®, Emsam^®, Zelapar^®)
  - Tranylcypromine (Parnate^®)

- Selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI) medications, such as:

- - Citalopram (Celexa^®)
  - Duloxetine (Cymbalta^®)
  - Desvenlafaxine (Pristiq^®)
  - Escitalopram (Lexapro^®)
  - Fluoxetine (Prozac^®, Sarafem^®, Selfemra™)
  - Fluvoxamine (Luvox^®, Luvox^® CR)
  - Levomilnacipran (Fetzima™)
  - Milnacipran (Savella™)
  - Paroxetine (Paxil^®, Paxil CR^®, Pexeva^®, Brisdelle™)
  - Sertraline (Zoloft^®)
  - Venlafaxine (Effexor^®, Effexor XR^®)

- Tricyclic antidepressants, such as:

- - Amitriptyline (Elavil^®)
  - Amoxapine (Asendin^®)
  - Clomipramine (Anafranil^®)
  - Desipramine (Norpramin^®)
  - Doxepin (Sinequan^®, Silenor^®)
  - Imipramine (Tofranil^®, Tofranil PM^®)
  - Maprotiline (Ludiomil^®)
  - Nortriptyline (Pamelor^®)
  - Protriptyline (Vivactil^®)
  - Trimipramine (Surmontil^®)

Amphetamines, amphetamine-like medications, and other stimulants, such as:
- Benzphetamine (Didrex^®)
- Dextroamphetamine (Dexedrine^®)
- Dextroamphetamine and amphetamine (Adderall^®)
- Dextroamphetamine-amphetamine extended release (Adderall XR^®)
- Lisdexamfetamine (Vyvanse^®)
- Methamphetamine (Desoxyn^®)
- Methylphenidate (Ritalin^®)
- Methylphenidate extended release (Concerta^®, Metadate CD^®, Metadate ER^®, Ritalin LA^®, Ritalin SR^®)
- Phendimetrazine (Bontril^®)
- Phentermine (Adipex-P^®)
- Sibutramine (Meridia^®)

Atomoxetine (Strattera^®)
Beta agonists, such as:
- Albuterol (Proventil HFA^®, Ventolin HFA^®, Proair HFA^®, Vospire ER^®)
- Arformoterol (Brovana^®)
- Formoterol (Foradil^®, Perforomist™)
- Levalbuterol (Xopenex^®, Xopenex HFA^®)
- Isoproterenol (Isuprel^®)
- Metaproterenol (Alupent^®)
- Pirbuterol (Maxair^®)
- Salmeterol (Serevent^®)
- Terbutaline (Brethine^®)

Buspirone (BuSpar^®)
Blood pressure medications
Catechol-o-methyltransferase (COMT) inhibitors, such as entacapone (Comtan^®, Stalevo^®) or tolcapone (Tasmar^®)
Cough, cold, and allergy products, such as:
- Dextromethorphan (Robitussin DM^® and many others)
- Naphazoline (various nasal and eye drops, such as Visine-A^®)
- Oxymetazoline (various nasal and eye drops, such as Afrin^®)
- Phenylephrine (Sudafed PE^® and many others)
- Propylhexedrine (Benzedrex^®)
- Pseudoephedrine (Sudafed^® and many others)