Zyvox Drug Interactions

Combining Zyvox with cyclobenzaprine may increase your risk of dangerous side effects, such as severe hypertension (high blood pressure) or serotonin syndrome, a potentially life-threatening reaction (see Zyvox Warnings and Precautions). If you take these drugs together, your healthcare provider will need to monitor you more closely.
Diabetes Medications
There have been a few reports of low blood sugar (hypoglycemia) in people taking Zyvox along with diabetes medications (including insulin medications and oral diabetes medications). Although a direct cause-and-effect relationship has not been established (it is possible that the low blood sugar was not caused by Zyvox), it is still a good idea to be cautious. You might want to check your blood sugar more often while taking Zyvox.
There is some evidence that taking disulfiram with Zyvox may cause dangerous central nervous system (CNS) side effects, such as extreme confusion, feeling disoriented, and seeing things that are not really there (visual hallucinations). Talk to your healthcare provider about this potential drug interaction before taking these medications together.
Levodopa Medications
Taking Zyvox with levodopa medications may cause dangerous side effects, such as high blood pressure (hypertension). If you must take these medications together, your healthcare provider will need to monitor you closely.
Combining Zyvox with meperidine may cause a dangerous and potentially life-threatening reaction called serotonin syndrome. If you take these medications together, your healthcare provider should monitor you closely for signs of this reaction (see Zyvox Warnings and Precautions for more information).
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Zyvox Medication Information

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