Drug Interactions With Pseudoephedrine

There are a number of medications that may cause pseudoephedrine drug interactions, including carbonic anhydrase inhibitors, sodium bicarbonate antacids, SNRI antidepressants, and monoamine oxidase inhibitors. Some of these drug interactions can increase your risk of serious problems (such as high blood pressure, an irregular heart rhythm, or seizures), while others can affect the drug levels in your blood.

Interactions With Pseudoephedrine: An Overview

Pseudoephedrine can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with pseudoephedrine include (but are not limited to):
 

 

    • Dronabinol (Marinol®)
    • Marijuana
    • Nabilone (Cesamet™)

 

  • Carbonic anhydrase inhibitors, such as:

 

    • Acetazolamide (Diamox®)
    • Dichlorphenamide (Daranide®)
    • Methazolamide

 

  • Iobenguane I 123 (AdreView™)
     
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Phenothiazine medications, including:

 

 

 

 

(It should be noted that many pseudoephedrine products also contain other active ingredients. This article focuses on the drug interactions for pseudoephedrine, not for the other active ingredients in such combination products.)
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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