Cold Home > Pneumonia Vaccine Drug Interactions

Warfarin, Orencia, prednisone, and certain other drugs can interact with the pneumonia vaccine. In people taking immunosuppressants, the immune system may not be able to respond fully to the vaccine. Extra care should be taken when vaccinating anyone taking a "blood-thinning" medication, such as heparin. To reduce your risk of interactions, tell your healthcare provider about all medications you are currently taking.

An Overview of Interactions With the Pneumonia Vaccine

As is standard with almost all vaccinations, the pneumonia vaccine (Pneumovax®, Prevnar 13®) should not be mixed with any other vaccines in the same vial or syringe. In addition, the pneumonia vaccine might react negatively with a few medications. Some of the drugs that may lead to interactions with the pneumonia vaccine include:
    • Chemotherapy (as well as radiation treatment)
    • Corticosteroids, such as:
      • Betamethasone (Celestone®)
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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