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Neo-Synephrine is an over-the-counter nasal spray used to temporarily relieve sinus and nasal congestion. Specifically, this nasal spray can help relieve congestion caused by allergies or the common cold. You should not use this medication for more than three days in a row, as it may worsen your congestion. Although most people have no problems with it, side effects can include sneezing or temporary burning.

What Is Neo-Synephrine?

Neo-Synephrine® (phenylephrine or oxymetazoline nasal spray) is a non-prescription medication used to temporarily relieve sinus and nasal congestion due to various causes, such as allergies or the common cold. Like other decongestant nasal sprays, this medication should not be used for more than three days in a row, due to the risk of the congestion becoming worse.
 
Neo-Synephrine comes in different forms -- some contain oxymetazoline and others contain phenylephrine.
 
(Click Neo-Synephrine Uses for more information, including possible off-label uses.)
 

Who Makes This Medication?

Neo-Synephrine is manufactured by Bayer HealthCare, LLC.
 

How Does It Work?

The active ingredients in Neo-Synephrine products (phenylephrine or oxymetazoline, depending on the particular product) belong to a group of drugs called decongestants. Specifically, they work by stimulating certain receptors known as alpha-adrenergic receptors. In the lining of the sinuses and nasal passages, this action causes the blood vessels to constrict, allowing less fluid to leave the blood vessels and decreasing inflammation. This helps to relieve nasal and sinus congestion.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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