Drug Interactions With Guaifenesin

In general, no medications are expected to react with guaifenesin when taken alone. However, this does not mean that drug interactions can be dismissed when taking guaifenesin. Because it is often combined with other medicines in cold and cough products, those other medicines could cause drug interactions. Check the ingredient list, and consult your healthcare provider before taking guaifenesin with any medications.

Does Guaifenesin Interact With Any Drugs?

Guaifenesin, an active ingredient in Mucinex®, Robitussin®, and many other medications, is unlikely to react with other medications. At this time, there are no known guaifenesin drug interactions.
However, this information should be interpreted cautiously, as guaifenesin is often marketed in combination with other active ingredients, such as antihistamines or cough suppressants, and these other medications are generally much more likely to cause drug interactions.
Check the product label to find out exactly which active ingredients are in your particular product. Only if your product contains just guaifenesin as the active ingredient, without any other active ingredients, can you be sure that drug interactions are unlikely.
Of course, guaifenesin products can interact with other guaifenesin products, at least in the sense that it would be easy to accidentally take a guaifenesin overdose if different products were taken at the same time. Because it is a common ingredient in a wide variety of cough and cold products, be sure to read all the labels carefully.
Although drug interactions with guaifenesin are unlikely, it is always a good idea to mention all medications, even over-the-counter (OTC) drugs and vitamins or supplements, whenever your healthcare provider asks about the medications you take. Your healthcare provider needs a complete list in order to provide a coordinated and appropriate course of care.
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Guaifenesin Medication Information

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