Drug Interactions With Gemifloxacin

More Detail on Drug Interactions With Gemifloxacin

The following sections explain in detail the potentially negative reactions that can occur when gemifloxacin is combined with any of the drugs listed above.
 
Aluminum, Calcium, or Magnesium Antacids
Aluminum, calcium, and magnesium can bind to gemifloxacin in the digestive tract, preventing it from being fully absorbed into the bloodstream. You should not take any aluminum or magnesium products within three hours before or two hours after a dose of gemifloxacin. Calcium appears to have less of an effect than aluminum or magnesium; however, it is still probably a good idea to avoid taking calcium and gemifloxacin at the same time, as a precaution.
 
Corticosteroids
Taking gemifloxacin with corticosteroids may increase your risk for tendon problems, such as tendonitis or tendon rupture. Older adults who take corticosteroids appear to have a greater risk for this reaction. If you take gemifloxacin with a corticosteroid, make sure to watch for any signs of tendon problems, such as tendon or joint pain or tenderness (see Factive and Tendon Rupture for more information).
 
Didanosine
Some forms of didanosine can bind to gemifloxacin in the digestive tract, preventing it from being completely absorbed into the bloodstream. This interaction pertains only to the chewable tablet and liquid forms of didanosine. Do not take didanosine chewable tablets or liquid within three hours before or two hours after a dose of gemifloxacin.
 
QT-Prolonging Medications
In general, gemifloxacin should be used with caution with any other medication that may cause QT prolongation (a certain change in the heart rhythm). Taking gemifloxacin with these medications may increase the risk of a life-threatening arrhythmia. Talk to your healthcare provider about this interaction if you take any QT-prolonging medications.
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