Drug Interactions With Diphenhydramine

There are a number of medications that could cause diphenhydramine drug interactions, including acetylcholinesterase inhibitor medicines, phenothiazine medications, and monoamine oxidase inhibitors. These negative drug interactions can increase your risk for developing certain side effects, such as drowsiness, dry mouth, constipation, dry eyes, or difficulty passing urine.

An Overview of Diphenhydramine Interactions

Diphenhydramine (Benadryl®, Sominex®, and many other brand names) can potentially interact with a number of other medicines. Some of the medications that may lead to diphenhydramine drug interactions include (but are not limited to):
 
  • Acetylcholinesterase inhibitor medications, including:

 

 

  • Anticholinergic drugs, such as:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Other medications that cause drowsiness, including, but not limited to:

 

 

  • Phenothiazine medications, including:

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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