When and How to Take the Drug

General considerations include the following:
  • This medication comes in many different forms. Depending on the particular product, it may be taken by mouth, applied to the skin, or injected into a vein or muscle.
  • You can take diphenhydramine with food or on an empty stomach. If the medication seems to bother your stomach, try taking it with a little food.
  • Because there are several different diphenhydramine products available, be sure to follow the instructions for your particular product.
  • For the medication to work properly, it must be taken as directed.

Diphenhydramine Dosing Information

The recommended dose will vary, depending on a number of factors, including:
  • The particular product
  • The medical condition being treated
  • Your age
  • How you respond to diphenhydramine
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Diphenhydramine Dosage for more information.)

Drug Interactions

Diphenhydramine can potentially interact with several other medicines (see Drug Interactions With Diphenhydramine).

What If I Take an Overdose of Diphenhydramine?

An overdose with this medication can cause serious problems. If you happen to take an overdose, seek immediate medical attention.
(Click Diphenhydramine Overdose for more information.)
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Diphenhydramine Hydrochloride Information

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