Diphenhydramine Dosage

Topical Diphenhydramine Dosing for Skin Itching and Pain
For diphenhydramine cream, spray, stick, or gel, a small amount of the product should be applied to the skin no more than three or four times daily. Do not use these products on children under the age of two years old. Do not use these products in combination with any other diphenhydramine product (including oral diphenhydramine products). Do not use these products over a large area of the body.
Diphenhydramine Dosing for Other Uses
For any other use, it is recommended that you consult your healthcare provider before taking diphenhydramine.

General Information on Dosing With Diphenhydramine

Considerations for people taking diphenhydramine include the following:
  • This medication comes in many different forms. Depending on the particular product, it may be taken by mouth, applied to the skin, or injected into a vein or muscle.
  • You can take diphenhydramine with food or on an empty stomach. If the medication seems to bother your stomach, try taking it with a little food.
  • Because there are several different diphenhydramine products available, be sure to follow the instructions for your particular product.
  • For the medication to work properly, it must be taken as directed.
  • If you are unsure about anything related to your dosage of diphenhydramine, please talk with your doctor, nurse, or pharmacist.
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