Drug Interactions With Dextromethorphan

When alcohol, antidepressants, amphetamines, or various other drugs are taken with dextromethorphan, negative interactions can occur. These reactions can lead to problems, including an increased risk for side effects and a potentially dangerous group of symptoms called serotonin syndrome. To prevent these and other potentially serious complications, talk to your healthcare provider about any other medicines, vitamins, or herbal supplements you are taking.

Does Dextromethorphan Interact With Other Drugs?

Dextromethorphan may react with a number of other medications. Some of the drugs that may lead to interactions with dextromethorphan include but are not limited to:
  • Alcohol
  • Amphetamines or amphetamine-like medications, such as:
  • Ergot medications, such as:
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)


  • Monoamine oxidase inhibitors (MAOIs), such as:
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Dextromethorphan Medication Information

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