Drug Interactions With Dextromethorphan

More Detail on Drug Interactions With Dextromethorphan

The following sections explain in detail the potentially negative reactions that can occur when dextromethorphan is combined with any of the drugs listed above.
 
Alcohol
Do not drink alcohol while taking dextromethorphan. Alcohol may increase the effects of this medication on the brain, potentially increasing the risk for dangerous problems, such as slow or irregular breathing or even a coma.
 
Amphetamines
Combining dextromethorphan with an amphetamine or an amphetamine-like medication can increase your risk for a serious problem known as serotonin syndrome (see Precautions and Warnings With Dextromethorphan for more information, including symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. Seek immediate medical care if you have any symptoms of serotonin syndrome.
 
Buspirone
Combining dextromethorphan with buspirone can increase your risk for a potentially dangerous problem known as serotonin syndrome (see Precautions and Warnings With Dextromethorphan for more information, including symptoms of serotonin syndrome). Talk to your healthcare provider before taking these medications together. Seek immediate medical attention if you have any symptoms of serotonin syndrome.
 
CYP 2D6 Inhibitors
The body breaks down dextromethorphan using enzymes in the liver known as CYP 2D6 enzymes. Some other medications (known as CYP 2D6 inhibitors) can decrease the activity of these enzymes. Combining dextromethorphan with one of these CYP 2D6 inhibitors may increase the level of dextromethorphan in your body, increasing your risk for potentially serious side effects. Talk to your healthcare provider before taking dextromethorphan with one of these medications.
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