Drug Interactions With Chlorpheniramine

Chlorpheniramine Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when chlorpheniramine is combined with any of the drugs listed above.
Acetylcholinesterase Inhibitor Medications
Taking chlorpheniramine with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent interactions from occurring. Check with your healthcare provider before combining these medications.
Anticholinergic Drugs
Combining an anticholinergic medication with chlorpheniramine (which has anticholinergic effects) can increase your risk of chlorpheniramine side effects, such as dry eyes or difficulty passing urine. Check with your healthcare provider before taking these medications together.
Monoamine Oxidase Inhibitors (MAOIs)
Taking chlorpheniramine and an MAOI together can prolong and intensify certain side effects of chlorpheniramine (such as drowsiness, dry eyes, or difficulty passing urine). Check with your healthcare provider before combining these medications.
Other Medications That Cause Drowsiness
Check with your healthcare provider before combining chlorpheniramine with any other medication that also causes drowsiness, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result.
Chlorpheniramine may increase the risk of a dangerous irregular heart rhythm (arrhythmia) due to a phenothiazine medication. In addition, combining chlorpheniramine with a phenothiazine increases the risk of excessive drowsiness.
Both pramlintide and anticholinergic medications (including chlorpheniramine) can slow down the movement of food through the digestive tract. Taking them together can increase the risk of constipation or nausea. Talk with your healthcare provider before combining these medications.
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Chlorpheniramine Medication Information

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