Augmentin XR Drug Interactions
Allopurinol (Aloprim, Zyloprim)
Combining allopurinol with antibiotics similar to Augmentin XR increases the risk of skin rashes. It is not known if this is also true with Augmentin XR.
Methotrexate (Rheumatrex, Trexall)
Penicillin-type antibiotics (including Augmentin XR) may decrease the body's ability to remove methotrexate, leading to high blood levels of methotrexate. Your healthcare provider may need to monitor you more closely in such a case.
Augmentin XR may decrease the effectiveness of mycophenolate mofetil. Check with your healthcare provider before taking these two medications together.
Despite the longstanding belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics. Ask your healthcare provider about whether or not you need a back-up method of birth control.
Oral Typhoid Vaccine
Augmentin XR may decrease the effectiveness of the oral typhoid vaccine. If you have taken Augmentin XR recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after stopping the antibiotic.
Probenecid can decrease the body's ability to remove Augmentin XR from the blood, potentially leading to high Augmentin XR blood levels. Talk with your healthcare provider before taking these medications together.
Tetracyclines may interfere with the effectiveness of Augmentin XR. Discuss this possibility with your healthcare provider before taking these drugs together.