Afrin Drug Interactions

Afrin Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Afrin is combined with any of the drugs listed above.
Taking Afrin with a cannabinoid drug increases the risk of a rapid heart rate (tachycardia), which can be dangerous. If you notice a rapid heart rate while using Afrin (with or without a cannabinoid), it is probably best to stop using it.
Iobenguane I 123
Afrin may interfere with tests that use iobenguane I 123. You should not take Afrin for several days before a laboratory test that involves iobenguane I 123 (your healthcare provider will give you more specific instructions).
Monoamine Oxidase Inhibitors (MAOIs)
If a significant amount of oxymetazoline (the active ingredient in Afrin) is absorbed into the bloodstream, it is possible that combining Afrin and an MAOI could cause life-threatening problems. If you are on an MAOI, make sure to check with your healthcare provider before using Afrin. Often, it is recommended to avoid Afrin while taking an MAOI or even within 14 days of taking an MAOI.
Tricyclic Antidepressants
It is possible that a tricyclic antidepressant could increase the risk of high blood pressure due to Afrin. This is most likely to happen if a significant amount of Afrin is absorbed into the bloodstream, which might occur if the spray runs down the back of the throat and is swallowed. If you take a tricyclic antidepressant, check with your healthcare provider before taking Afrin.

Final Thoughts on Afrin Drug Interactions

It is possible that not all drug interactions with Afrin were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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